"This volume is a unique and complete source of information on the epidemiology and prevention of cancer."--Anticancer Research

This much anticipated Third Edition provides a comprehensive presentation of the global burden and patterns of cancer occurrence, along with new developments in our understanding of cancer causation and prevention. Special attention is given to epidemiologic approaches that incorporate molecular biomarkers based on genomic and other emerging technologies, providing new insights into the role of genetic predisposition and gene-environment interactions in cancer induction. In addition, new chapters are included on social class disparities in cancer incidence and mortality, the role of obesity and physical inactivity in cancer etiology, the potential effects of electromagnetic fields and rediofrequency radiation, and the principles of cancer chemoprevention. The textbook is organized into five sections: Basic Concepts; The Magnitude of Cancer; The Causes of Cancer; Cancer by Tissue of Origin; Cancer Prevention and Control. In this new edition, Drs. David Schottenfeld and Joseph F. Fraumeni, Jr. have enlisted three distinguished Associate Editors: Drs. Jonathan Samet of Johns Hopkins University, Graham Colditz of Harvard University and Alice Whittemore of Stanford University.

Part I: Basic Concepts 1. Cause and Cancer Epidemiology, Steven N. Goodman, Jonathan M. Samet 2. Morphologic and Molecular Classification of Human Cancer, Thomas J. Giordano 3. Cancer Precursors, Thomas E. Rohan, Donald E. Henson, Eduardo L. Franco, and Jorge Albores-Saavedra 4. Molecular and Genetic Events in Neoplastic Transformation, Ayse E. Erson and Elizabeth M. Petty 5. Risk Assessment of Carcinogenetic Hazards, Leslie Stayner, Paolo Boffetta, and Harri Vainio 6. Application of Biomarkers in Cancer Epidemiology, Monsterrat Garcia-Closa, Roel Vermeulen, Mark E. Sherman, Lee Moore, Martyn T. Smith, and Nathaniel Rothman 7. Genetic Concepts and Methods in Epidemiologic Research, Neil Risch and Alice S. Whittemore

Part II: The Magnitude of Cancer 8. International Patterns of Cancer Incidence and Mortality, D. Max. Parkin and Freddie Bray 9. Cancer Incidence, Mortality and Patient Survival in the United States, Lynn A.G. Ries and Susan S. Devesa 10. Socioeconomic Disparities in Cancer Incidence and Mortality, Ichiro Kawachi and Candyce Kroenke 11. Migrant Studies, Laurence N. Kolonel and Lynne R. Wilkens 12. Economic Impact of Cancer in the United States, Martin L. Brown and K. Robin Yabroff

Part III: The Causes of Cancer 13. Tobacco and Cancer, Michael J. Thun and S. Jane Henley 14. Alcohol, James R. Marshall and Jo Freudenheim 15. Ionizing Radiation, John D. Boice 16. Solar Radiation, Adele C. Green, David C. Whiteman 17. Electromagnetic Fields and Radiofrequency Radiation, David Savitz and Anders Ahlbom 18. Occupation, Jack Siemiatycki, Lesley Richardson and Paolo Boffetta 19. Air Pollution, Jonathan M. Samet and Aaron J. Cohen 20. Water Contaminants, Kenneth P. Cantor, Mary H. Ward, Lee Moore, and Jay Lubin 21. Diet and Nutrition, Walter C. Willett 22. Obesity and Body Composition, Rachel Ballard-Barbash, Christine Friedenreich, Martha Slattery, and Inger Thune 23. Physical Activity, I-Min Lee and Yuko Oguma 24. Exogenous Hormones, James V. Lacey, Graham A. Colditz, and David Schottenfeld 25. Pharmaceuticals Other than Hormones, Laurel A. Hable and Gary D. Friedman 26. Infectious Agents, Nancy E. Mueller, Brenda Birmann, Julie Parsonnet, Mark Schiffman, and Sherri Stuver 27. Immunologic Factors, Gareth J. Morgan, Martha S. Linet, and Charles S. Rabkin 28. Hereditary Neoplastic Syndromes, Noralane M. Lindor, Carl J. Lindor, and Mark H. Greene 29. Genetic Modifiers of Cancer Risk, Neil E. Caporaso

Part IV: Cancer by Tissue of Origin 30. Cancers of the Nasal Cavity and Paranasal Sinuses, Alyson J. Littman, Thomas L. Vaughan 31. Nasopharyngeal Cancer, Mimi C. Yu, Jian-Min Yuan 32. Larynx, Andrew F. Olshan 33. Cancer of the Lung, Margaret R. Spitz, Xifeng Wu, Anna Wilkinson, and Qingyi Wei 34. Pleural and Peritoneal Neoplasms, Paolo Boffetta and Leslie T. Stayner 35. Cancers of the Oral Cavity and Pharynx, Susan T. Mayne, Douglas E. Morse, and Deborah M. Winn 36. Esophageal Cancer, William J. Blot, Joseph K. McLaughlin, and Joseph F. Fraumeni, Jr. 37. Stomach Cancer, Atsuko Shibata and Julie Parsonnet 38. Cancer of the Pancreas, Kristin E. Anderson, Thomas M. Mack, and Debra Silverman 39. Liver Cancer, W. Thomas London and Katherin A. McGlynn 40. Biliary Tract Cancer, Ann W. Hsing, Asif Rashid, Susan S. Devesa, and Joseph F. Fraumeni, Jr. 41. Cancers of the Small Intestine, Jennifer Beebe-Dimmer and David Schottenfeld 42. Cancers of the Colon and Rectum, Edward Giovannucci 43.