With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers
facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The
Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides
quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical
methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights
the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis
for the generation of molecular diversity.
Key Features
* Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and
analytical methods
* Serves as a laboratory manual for bench chemists
* Includes a chapter on linkers to assist in choice of linking strategy
* Discusses strengths and limitations of the various methods
* Contains a structural index showing functional group transformations in solid-phase synthesis